Risk of peripheral neuropathy associated with supplemental vitamin B6

The Health Sciences Authority (HSA) would like to update on the risk of peripheral neuropathy associated with excessive intake of vitamin B6. The maximum allowable limit for vitamin B6 in health supplements is 100mg/day for adults. Excessive consumption of vitamin B6 can occur from concurrent intake of more than one health supplements containing vitamin B6.

Peripheral neuropathy is characterised by tingling, burning, or numbness, usually in the hands or feet. The underlying reasons for the peripheral neuropathy have not been clearly established at this stage. In most of these cases, the symptoms resolved upon stopping the use of the products.

You may wish to inform users of such products on this potential risk via labelling. Should your company receive feedback from consumers about possible adverse events such as peripheral tingling, burning or numbness, please advise them to seek medical attention. Companies are advised to monitor these feedback from consumers and report to HSA using this online reporting form.

Companies dealing with health supplements containing vitamin and minerals are reminded to ensure that their products comply with the requirements, including the maximum limit for vitamins and minerals, stipulated in the guidelines on health supplements set out by the HSA. For more information on the maximum limits for vitamins and minerals, and requirements for health supplements, please refer to the guidance at https://www.hsa.gov.sg/health-supplements/overview.

For further clarification, please email us at HSA_CHP@hsa.gov.sg

Published: 23 May 2023

Regulatory Updates