Wellbutrin SR tablet 150mg (Bupropion Safety update – possible increased risk of some congenital cardiovascular malformations)

GlaxoSmithKline would like to inform healthcare professionals of the possible increased risk of congenital cardiovascular malformations associated with bupropion. Results from an epidemiology study investigating the risk of congenital cardiovascular malformations following bupropion exposure during the first trimester of pregnancy as well as findings from other studies suggest a potential increased risk of some congenital cardiovascular malformations such as ventricular septal and left outflow tract heart defects. The pregnancy and pre-clinical safety data sections of the product inserts for all bupropion containing products would be updated accordingly to warn of this potential increase in risk. Healthcare professionals are encouraged to consider this new information and to weigh the option of alternative treatments in women who are pregnant or are planning to become pregnant.

 
 
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.hpp.moh.gov.sg/, and follow the procedures below to access the MOH Alert system.

Step 1: Scroll down to the bottom navigation panel of the HPP web page. Under the Healthcare Professionals section, expand the dropdown option for ‘Healthcare Professional Portal’ and select your profession. You will be redirected to the specific HPP web page to log in.

Step 2: Click on the Restricted Content icon on the left panel of the web page and log in via SingPass.

Step 3: Click on the MOH Alert icon under the ‘Applications’ section.

Step 4: Click on the Drug Alert tab to view the DHCPLs.