Update to the Primperan® (metoclopramide) package insert for Singapore- updated indications and posology to minimise risk of adverse effects (particularly neurological effects)

Sanofi-aventis Singapore Pte. Ltd. would like to inform healthcare professionals of the safety updates to the local package inserts for Primperan® Injection 10 mg/2 ml and Tablet 10 mg to minimise the risks of neurological and other dose-related adverse reactions. Metoclopramide should only be prescribed for short-term use at recommended doses and dose-intervals. Intravenous doses should be administered as a slow bolus. Use in adults are restricted to short-term prevention and treatment of nausea and vomiting, including that associated with chemotherapy, radiotherapy, surgery and migraine. Children less than 1 year of age are contraindicated from use due to the risk of neurological reactions and methaemoglobinaemia. In children aged 1-18 years, metoclopramide is restricted as a second option for treatment of established post-operative nausea and vomiting (for intravenous route only) and prevention of chemotherapy-induced nausea and vomiting. Please refer to the letter for more details.
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.hpp.moh.gov.sg/, and follow the procedures below to access the MOH Alert system.

Step 1: Scroll down to the bottom navigation panel of the HPP web page. Under the Healthcare Professionals section, expand the dropdown option for ‘Healthcare Professional Portal’ and select your profession. You will be redirected to the specific HPP web page to log in.

Step 2: Click on the Restricted Content icon on the left panel of the web page and log in via SingPass.

Step 3: Click on the MOH Alert icon under the ‘Applications’ section.

Step 4: Click on the Drug Alert tab to view the DHCPLs.