New identified risk of hepatotoxicity (including hepatic failure) in patients treated with Imbruvica®

A Dear Healthcare Professional Letter has been issued by Johnson & Johnson International (Singapore) Pte Ltd to inform healthcare professionals about a new identified risk of hepatotoxicity, including hepatic failure, which has been reported in patients treated with Imbruvica®. This causal association is based on a recent cumulative review of data from clinical trials, post-marketing cases and literature by Johnson & Johnson and the Imbruvica® package insert will be updated accordingly. Healthcare professionals are advised to discuss with patients the risks associated with the use of Imbruvica®, including hepatoxicity and hepatic failure. It is recommended to assess liver function before initiating treatment with Imbruvica® and monitor patients periodically for changes in liver function parameters during treatment. Please refer to the letter for details.

 

Healthcare professional, Industry member, Therapeutic Products
Published:

Dear Healthcare Professional Letters

30 Sep 2024

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.hpp.moh.gov.sg/, and follow the procedures below to access the MOH Alert system.

Step 1: Scroll down to the bottom navigation panel of the HPP web page. Under the Healthcare Professionals section, expand the dropdown option for ‘Healthcare Professional Portal’ and select your profession. You will be redirected to the specific HPP web page to log in.

Step 2: Click on the Restricted Content icon on the left panel of the web page and log in via SingPass.

Step 3: Click on the MOH Alert icon under the ‘Applications’ section.

Step 4: Click on the Drug Alert tab to view the DHCPLs.