New data suggest that individuals who were previously vaccinated with Mencevax ACWY™ but remain at high risk of exposure to serogroups A, W-135 and Y should be considered for earlier revaccination

GlaxoSmithKline (GSK) would like to inform healthcare professionals of the new antibody persistence data for Mencevax ACWY™.  The immunity to serogroups W-135 and Y in individuals 11-55 years of age who were vaccinated two years earlier with Mencevax ACWY™ is 24.0% and 44.0%, respectively. Limited data showed a waning of serum bactericidal antibody titres against serogroup A one year post-vaccination when using human complement in the assay (hSBA). Individuals remaining at high risk of exposure to serogroups A, W-135 and Y should be considered for earlier revaccination according to local recommendations. It is to be noted that re-vaccination with group C polysaccharide-containing vaccines may induce lower antibody responses to meningococcal group C polysaccharide compared to primary vaccination. The product information for Mencevax ACWY™ will be updated to include these new antibody persistence data. Please refer to the letter for more details. 
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.hpp.moh.gov.sg/, and follow the procedures below to access the MOH Alert system.

Step 1: Scroll down to the bottom navigation panel of the HPP web page. Under the Healthcare Professionals section, expand the dropdown option for ‘Healthcare Professional Portal’ and select your profession. You will be redirected to the specific HPP web page to log in.

Step 2: Click on the Restricted Content icon on the left panel of the web page and log in via SingPass.

Step 3: Click on the MOH Alert icon under the ‘Applications’ section.

Step 4: Click on the Drug Alert tab to view the DHCPLs.