Important safety information on Strattera® (atomoxetine) and increased blood pressure and heart rate

Eli Lilly (S) Pte Ltd would like to update healthcare professionals on safety information from clinical studies regarding risk of increased blood pressure and increased heart rate with the use of atomoxetine. A recent analysis of combined data from Eli Lilly sponsored trials has indicated that a proportion of atomoxetine-treated patients (approximately 5 to 10% of children and adults) experienced clinically important changes in heart rate (20 beats per minute or greater) or blood pressure (15 to 20 mm Hg or greater). The magnitude of the increase in blood pressure and heart rate could be a potential risk in patients with severe cardiovascular disorders. Although the current prescribing information for Strattera® already contains warnings that atomoxetine may increase blood pressure and heart rate, it will be further strengthened to highlight the above safety information.

 
 
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.hpp.moh.gov.sg/, and follow the procedures below to access the MOH Alert system.

Step 1: Scroll down to the bottom navigation panel of the HPP web page. Under the Healthcare Professionals section, expand the dropdown option for ‘Healthcare Professional Portal’ and select your profession. You will be redirected to the specific HPP web page to log in.

Step 2: Click on the Restricted Content icon on the left panel of the web page and log in via SingPass.

Step 3: Click on the MOH Alert icon under the ‘Applications’ section.

Step 4: Click on the Drug Alert tab to view the DHCPLs.