Glivec® (imatinib)- Need to screen patients for hepatitis B virus (HBV) infection before treatment due to risk of HBV reactivation

Novartis would like to inform healthcare professionals of the risk of hepatitis B (HBV) reactivation associated with the use of Glivec® (imatinib) in patients who are chronic HBV carriers. Cases of reactivation of HBV can occur in patients who are chronic carriers of this virus after receiving BCR-ABL tyrosine kinase inhibitors (TKIs), such as imatinib. Case reports indicate that HBV reactivation may occur at any time during BCR-ABL TKIs treatment. Some of these cases resulted in acute hepatic failure or fulminant hepatitis leading to liver transplantation or a fatal outcome. Healthcare professionals are advised to test patients for HBV infection before initiating treatment with imatinib. Patients currently on imatinib should have baseline testing for HBV infection in order to identify chronic carriers of the virus. Experts in liver disease and in the treatment of HBV should be consulted before treatment is initiated in patients with positive HBV serology (including those with active disease) and for patients who test positive for HBV infection during treatment. Carriers of HBV who require treatment with imatinib should be closely monitored for signs and symptoms of active HBV infection throughout therapy and for several months following termination of therapy. The local package inserts for Glivec® products will be updated with the new information.
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.hpp.moh.gov.sg/, and follow the procedures below to access the MOH Alert system.

Step 1: Scroll down to the bottom navigation panel of the HPP web page. Under the Healthcare Professionals section, expand the dropdown option for ‘Healthcare Professional Portal’ and select your profession. You will be redirected to the specific HPP web page to log in.

Step 2: Click on the Restricted Content icon on the left panel of the web page and log in via SingPass.

Step 3: Click on the MOH Alert icon under the ‘Applications’ section.

Step 4: Click on the Drug Alert tab to view the DHCPLs.