Antibody-Mediated Pure Red Cell Aplasia (PRCA) case cluster observed with subcutaneous administration of erythropoietin (EPO) Eprex® at a Singapore Institution

Janssen, a division of Johnson & Johnson Pte Ltd (“Janssen”), is informing healthcare professionals of an increase in the number of EPO antibody-mediated PRCA cases with onset in 2012 and 2013 observed from one institution in Singapore. These cases comprise a cluster of 6 Eprex® reports and were reported in patients who had received subcutaneous administration of Eprex® at some point during their treatment. Janssen wishes to reinforce the vigilance for, and identification of, EPO antibody-mediated PRCA and the appropriate storage and handling of Eprex® that is described in the Singapore prescribing information. Please refer to the Dear Healthcare Professional Letter for more details.
Healthcare professional, Therapeutic Products
Published:

Dear Healthcare Professional Letters

12 Dec 2019

Only abstracts of the Dear Healthcare Professional Letters (DHCPL) are provided on this website. Details of the letters can be found on the MOH Alert System, which is accessible via the Health Professionals Portal (HPP). HPP is a one-stop portal for all healthcare professionals in Singapore. Dentists, medical doctors and pharmacists may access HPP at https://www.moh.gov.sg/hpp/, and follow the procedures below to access the MOH Alert system.

Step 1: On the top navigation ribbon of webpage, select 'For Healthcare Professionals' followed by 'Health Professionals Portal' and click on the choice of profession. User will be redirected to the specific HPP webpage for the selected profession.

Step 2: Click on the Restricted Content icon on the left panel of webpage and login via SingPass.

Step 3: Click on the MOH Alert icon under ‘Applications’ section

Step 4: Click on the Drug Alert tab to view the DHCPLs.